comparison of sublingual and vaginal misoprostol for second-trimester pregnancy terminations.

نویسندگان

forozan milani reproductive health research center, guilan university of medical sciences, rasht, iran.

seyede hajar sharami reproductive health research center, guilan university of medical sciences, rasht, iran.

saeedeh arjmandi reproductive health research center, guilan university of medical sciences, rasht, iran.

چکیده

objective: comparing sublingual and vaginal misoprostol in second trimester pregnancy termination. materials and methods: in this study 268 women at 12-24 weeks of gestation candidate for pregnancy termination were enrolled. women were randomly divided in two groups. the first group received 400 µg sublingual misoprostol and vaginal placebo and the second group received 400 µg vaginal misoprostol and sublingual placebo every 4 hours for a maximum of five doses. the course of misoprostol was repeated if the women did not abort within 24 hours. } results: the median induction-to-abortion interval was shorter in sublingual group (12/72 hours in sublingual and 14/67 hours in vaginal). there was no significant difference in the success rate at 24 and 48 hours and in side effects. the preference for the sublingual route of administration was higher.both vaginal and sublingual misoprostol are effective for medical abortion in second trimester termination. conclusion: but it appears from shorter induction interval in sublingual and higher acceptability that sublingual route is a better choice.

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منابع مشابه

Comparison of Sublingual and Vaginal Misoprostol for Second-Trimester Pregnancy Terminations

OBJECTIVE Comparing sublingual and vaginal misoprostol in second trimester pregnancy termination. MATERIALS AND METHODS In this study 268 women at 12-24 weeks of gestation candidate for pregnancy termination were enrolled. Women were randomly divided in two groups. The first group received 400 µg sublingual misoprostol and vaginal placebo and the second group received 400 µg vaginal misoprost...

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Comparison of Efficacy and Side Effects of Different Administration Routes of Misoprostol (Oral, Vaginal, and Sublingual) for Second-Trimester Abortion

Background The current study was designed to compare the effectiveness and side effects of oral, vaginal, and sublingual misoprostol in termination of second-trimester pregnancy. Materials and Methods: In this clinical trial (2014 to 2015), 85 pregnant women in the second trimester of pregnancy were included in Imam Reza hospital, Kermanshah, Iran. They were randomly divided into three groups a...

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Comparison of vaginal and sublingual misoprostol for second trimester abortion: randomized controlled equivalence trial.

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Comparison of the Efficacy of Vaginal Misoprostol with and without Laminaria in Second Trimester Induction Abortion

Background & Aims: Therapeutic abortion in the second trimester pregnancy is the choice treatment in cases with severe anomalies or intrauterine fetal death. It can be done by a number of medical (e.g. misoprostol) or mechanical methods (e.g. laminaria). The aim of this study was to compare the efficacy of misoprostol alone and misoprostol in combination with laminaria in the induction of secon...

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Mifepristone and oral, vaginal, or sublingual misoprostol for second-trimester abortion: a randomized controlled trial.

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Comparative Study of Misoprostol in First and Second Trimester Abortions by Oral, Sublingual, and Vaginal Routes.

OBJECTIVE To identify an effective misoprostol-only regimen for termination of pregnancy between 12 and 20 weeks of gestation, a prospective randomized study comparing sublingual, vaginal, and oral routes of administration of misoprostol was done. METHODS One hundred and fifty women (12-20 weeks gestation) were randomly divided into three groups and given 400 mcg misoprostol sublingually, vag...

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عنوان ژورنال:
journal of family and reproductive health

جلد ۸، شماره ۱، صفحات ۴۱-۴۴

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